Sysmex XN 1000

Sysmex Corporation. Japan

DESIGNED FOR VERSATILITY

The flow fluorescence cytometry method is used for leukocyte counting and differential analysis, as well as for determining the count of reticulocytes (RET channel), platelets (PLT-F channel), and leukocyte precursor cells (WPC channel).

The touchscreen and graphical interface make operation simple and convenient.

The user programs the rules and the research algorithm themselves.

The XN-1000 will ensure maximum efficiency in the use of laboratory space.

The availability of various reagent pack sizes for XN-series analyzers, combined with RFID tags and a cartridge-based packaging system for specialized intercalating dyes, ensures that every milliliter of reagent is used strictly for its intended purpose.

Automated 6-diff hematology analyzer

High-throughput automated 6-part differential hematology analyzer with reticulocyte analysis and body fluid cytological analysis capabilities

Throughput of 100 samples per hour

The option for manual sample introduction allows for working with small blood volumes.

Automatic sample feeding with simultaneous loading of 5 racks of 10 tubes each

The automatic reflex testing function increases the efficiency of the examination.

Qualitative and quantitative assessment and determination of the entire hematopoiesis process

Configurations

XN-1000 (Pure) is an analyzer consisting of one XN-10 module, with a throughput of 100 samples per hour (in CBC+DIF mode). It features automatic sample loading, with the option for manual loading. It does not include an automatic reflex testing function.

XN-1000 (DIFF) – an analyzer consisting of one XN-10 module, with a throughput of 100 samples per hour (CBC+DIFF mode), featuring automatic sample loading (with manual loading capability) and automatic reflex testing.

XN-1000 (WPC) is a hematology analyzer system consisting of one XN-20 module, with a throughput of 100 samples per hour (in CBC+DIF mode). It features automatic sample loading, with an option for manual loading, and includes an automatic reflex testing function.

Leukopoiesis — the differentiation of the leukocyte count into 6 leukocyte subpopulations, including immature granulocytes, as well as the ability to perform an accurate leukocyte count and differentiate their subpopulations even in cases of severe leukopenia (WBC < 1000/µL).

Erythropoiesis — precise and highly sensitive counting of erythroblasts (NRBCs), direct assessment of the hemoglobinization level of reticulocytes (RET-He) and erythrocytes (RBC-He), the immature reticulocyte fraction (IRF), and the reticulocyte production index.

Thrombopoiesis — accurate platelet counting, even in the presence of severe thrombocytopenia (PLT-O, PLT-F), with quantification of the Immature Platelet Fraction (IPF)

Diagnostic modules

XN-10 Automated Hematology Analysis Module:

1. Basic CBC+DIFF mode

2. Optional diagnostic channels:

RET channel (analysis of reticulocytes and reticulocyte parameters)

PLT-F channel (fluorescent platelet analysis, including assessment of the immature platelet fraction)

BF channel (cytological analysis of body fluids)

XN-20 Automated Hematology Analysis Module:

1. Basic mode: CBC+DIFF, RET channel (analysis of reticulocytes and reticulocyte parameters), WPC channel (channel for diagnosing neoplastic processes and counting hematopoietic precursor cells)

2. Optional diagnostic channels:

PLT-F channel (fluorescent platelet analysis with assessment of the immature platelet fraction)

CHARACTERISTICS

Measurement principle

CBC+DIFF mode parameters (standard for XN-10/20)

RET channel parameters (optional for XN-10 and standard for XN-20)

PLT-F channel parameters (optional for XN-10 and XN-20)

WPC Channel Parameters (base for XN-20)

WBC/DIFF/RET/PLT-F/WPC: Fluorescent flow cytometry

RBC/PLT: Impedance method with hydrodynamic focusing

HGB (Hemoglobin): Cyanide-free SLS method

WBC, NRBC%, NRBC#, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, RDW-SD, RDW-CV, MicroR%, MacroR%, PDW, MPV, P-LCR, PCT, NEUT%, NEUT#, LYMPH%, LYMPH#, MONO%, MONO#, EO%, EO#, BASO%, IG#

Optional: Extended Inflammation Parameters license: NEUT-GI, NEUT-RI, RE-LYMP%, RE-LYMP#, AS-LYMP%, AS LYMP#

Optional: TNC, TNC-C, TNC-D, WBCC, WBC-D, NE-SSC, NE-SFL, NEFSC, HFLC#, HFLC%

RET%, RET#, IRF, LFR, MFR, HFR, RET-He, RBC-He, Delta-He, HYPO-He%, HYPER He%, PLT-O

Additional: FRC#, FRC%, RPI, RBC-O, HGB O, MCHC-O

PLT-F, IPF, IPF#

Highly specific marker for neoplastic processes

Optional: stem cell count (XN Stem Cells licence): HPC%, HPC#

BF-channel parameters (optional for XN-10 and XN-20)

Main: WBC-BF, RBC-BF, MN%, MN#, PMN%, PMN#, TC-BF#

Additional: HF-BF#, HF-BF%, NE-BF#, NE BF%, LY-BF#, LY-BF%, MOBF#, MO-BF%, EO-BF#, EO-BF%, RBC-BF-2

Throughput capacity

CBC+DIFF – complete blood count (CBC) with a 6-part white blood cell differential – 100 samples/hour

CBC+DIFF+RET – complete blood count (CBC) with a 6-part white blood cell differential and reticulocyte analysis (RET license) – 83 samples/hour

BF analysis – cytological examination of body fluids – 40 samples/hour

Sample aspiration volume

Hematology analysis module (XN-10/20):

88 µL of venous or capillary blood with EDTA for CBC+DIFF, CBC+DIFF+RET, and CBC+DIFF+RET+PLT-F modes

88 µL of a biological fluid sample for the BF analysis mode

Device memory

Complete test results from 100,000 samples

100,000 patient information records

Quality control (QC) data: 99 files (300 charts per file); X-bar control charts (Levey-Jennings charts) – 94 files (300 charts per file); X-barM control charts – 5 files (300 charts per file)

5,000 records of reagent replacements

Quality Control

XN CHECK L1, XN CHECK L2, XN CHECK L3: Material (3 levels) for quality control of all parameters in CBC+DIFF+RET mode. Pack size: 3 ml per level.

XN Check BF: Material (2 levels) for quality control of all parameters in CBC+DIFF+RET mode. Pack size: 3 ml per level.

Reagents

SVS+DIFF mode, BF mode:

CELLPACK DCL 10/20 l

SULFOLYSER 3 x 500 ml / 5 l

LYSERCELL WDF 2 l

FLUOROCELL WDF 2 x 22 ml

LYSERCELL WNR 5L

FLUOROCELL WNR 2X82ML

CELLCLEAN 50 ml

RET mode:

CELLPACK DFL 2 x 1.5 l

FLUOROCELL RET 2 x 12 ml

PLT-F mode:

CELLPACK DFL 2 x 1.5 l

Fluorocell PLT 2 x 12 ml

WPC mode:

Lysercell WPC 2 x 1.5 l

Fluorocell WPC 2 x 12 ml

Dimensions

Configurations

The following features can be added to the basic configuration of any model in the XN-L series of analyzers:

450 x 460 x 510 mm / 35 kg

The basic configuration includes the capability for a complete blood count (CBC) with a 6-part white blood cell differential (a total of 40 parameters). In this basic configuration, the analyzer has a throughput of 60 samples per hour.

1. Reticulocyte analysis function (XN-L RET licence) — counting and analysis of reticulocytes, red blood cells, and platelets (19 parameters in total)

2. Cytological analysis function for body fluids (cerebrospinal fluid, effusions, synovial fluid, etc.) — XN-L BF licence (18 parameters in total)

3. Leukopenic sample analysis function (XN-L L-WBC licence) — improves the accuracy of white blood cell (WBC) counts and differential analysis in samples with a low WBC count (less than 1 × 10⁹/L)

4. "Aged" sample identification and analysis function (AGED SAMPLE IDENTIFIER) — designed for analyzing samples that cannot be processed within 8 hours of collection

5. Throughput enhancement function (XN-L Speed-up licence) — reduces the analysis time per sample and increases throughput to up to 70 samples per hour